Phase II Metabolism

Phase II Metabolism

Excerpt from Cafer's Psychopharmacology, available soon on Amazon
Phase II metabolism mnemonic by Jason Cafer MD
Phase II reactions typically involve conjugation of a substrate with glucuronic acid. This makes it water soluble and prepped for renal excretion.
Conjugation with glucuronic acid by Jason Cafer MD
The responsible enzyme is UDP-glucuronosyltransferase, abbreviated UGT, as in “U Got Tagged” with glucuronic acid. 


Medications metabolized primarily by Phase II are relatively immune to drug interactions. Examples of clinically relevant Phase II interactions are those involving lamotrigine (Lamictal) as a substrate.

Copyright 2020 CaferMed LLC

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