Induction of Cytochrome P450 enzymes
Excerpt from Cafer's Psychopharmacology, available soon from Amazon
ENZYME INDUCTION
Theopposite of inHibition is inDuction. InDuction occurs when an inDucer
stimulates the liver to produce extra enzymes, leading to enhanced metabolism
and quicker clearance of victim drugs. More often than not, an inducer is itself
a substrate of the enzyme.
stimulates the liver to produce extra enzymes, leading to enhanced metabolism
and quicker clearance of victim drugs. More often than not, an inducer is itself
a substrate of the enzyme.
The D is for Down, i.e., Decreased serum concentrations of victim substrates.
Unlike inHibition (H for Hurried), inDuction is Delayed, not taking full effect
for 2 to 4 weeks while we...
Unlike inHibition (H for Hurried), inDuction is Delayed, not taking full effect
for 2 to 4 weeks while we...
 |
| wait for the liver to ramp up enzyme production. |
InDucers will be depicted by:
THE SHREDDERS
The “shredders” are four strong inDucers of several CYPs, which cause countless chemicals to be quickly expelled from the body:
- carbamazepine (Tegretol) – antiepileptic
- phenobarbital (Luminal) – barbiturat
- phenytoin (Dilantin) – antiepilepti
- rifampin (Rifadin) – antimicrobial
St John’s Wort (herbal antidepressant) also inDuces several CYPs, but does so with less potency than the four shredders.
Can shredding be problematic even if the patient is not taking a victim medication? Consider this:
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